Reductive amination using sodium cyanoborohydride. The reaction takes place in two parts.

Reductive amination using sodium cyanoborohydride. The second step is the reduction of the imine to an amine using an reducing agent. Itwas es- narily from aniline hydrochloride and sodium borohydride in The literature is replete with publications that document the very successful use of sodium cyanoborohydride in a wide scope of applications in reductive amination reactions. It is one of the key approaches to C–N bond construction due to its operational easiness and a wide toolbox of protocols. Many other reducing agents (NaBH 4, NaBH (OAc) 3, etc. Sodium triacetoxyborohydride was successfully used in the reductive amination of variety of aldehydes and ketones with primary and secondary amines. Several reducing disaccharides have been conjugated with protein carriers by linking the α- amino group of the lysine side chain [128]. First, the reducing agent must be stable in water, unreactive with aldehydes, and yet reactive with iminium ions. 3). It selectively reduces the imine intermediate formed between an amine and a carbonyl compound (such as an aldehyde or ketone) to form a new secondary amine. Both aromatic and aliphatic aldehyde reacted well to give the corresponding amines in excellent yields. Uses Sodium cyanoborohydride is a mild reducing agent. The cyanoborohydride offers five times milder reduction compared to borohydride in the reductive amination process, reducing the Schiff’s bases, but not the aldehydes2. Very high yields of oligosaccharide labeling have been reported using these reductive agents [9]. Sodium cyanoborohydride is preferred as a reducing agent over sodium borohydride as the latter will also reduce the reactive aldehydes to hydroxyls at the same time as reducing the Schiff’s bases. Jan 1, 2010 · In this study, we have described an efficient, rapid and chemoselective method for the synthesis of amines by reductive amination of carbonyl compounds with various amines using sodium borohydride and silica chloride. At pH 6-8, aldehydes and ketones undergo reductive amination Reduction of oximes, at low pH Have a close look at the CyanoBoroHydride Sodium CyanoBoroHydride (NaBH3CN) is a selective reducing agent used for a variety of chemical reductions, including aldehyde, ketones, oximes, enamines, reductive aminations of aldehydes and ketones, and reductive alkylations of amines and hydrazines. The most effective reducing agent for this reaction is sodium cyanoborohydride (NaBH3CN). NaBH 3 CN is a relatively weak reductant which works under mildly acidic conditions. Get expert tips on reaction conditions, mechanisms, and best practices from a leading sodium cyanoborohydride supplier. Reductive amination produces different degrees of substitution of amines depending on the starting amine substrate. The Encyclopedia of Organic Reagents (or the condensed Handbook of Reagents for Organic Synthesis) is a helpful reference to introduce you to reagents and the Using the approach described in this application note, the Synple Chem synthesizer offers an easy and fast automated method for the coupling of amines and carbonyl compounds using a reductive amination process. Typical reducing agents in reductive amination include metal hydrides like sodium borohydride (NaBH 4) or sodium cyanoborohydride (NaBH 3 CN). We report the development and qualification of a rapid, quantitative GC derivatization method using Aug 5, 2017 · The most widely applied reducing agents for these reductive amination reactions are sodium cyanoborohydride and 2-picoline borane. The Reductive amination and acyl reduction of amides are the major synthetic routes for amine synthesis, especially secondary and tertiary amines. Sodium Apr 30, 2023 · 3. 6 mg, 0. Home Reductive Amination Ex [NaBH (OAc)3] Reductive Amination NaBH (OAc) 3 Examples: Example 1 A slurry of the amine (50 mg, 0. Aug 8, 2020 · The selection of suitable hydride reagents and reaction conditions are important factors in determining the efficiency and selectivity of RA reactions. Reductive amination with sodium cyanoborohydride is a very time consuming reaction and typically requires a few days to reach completion (Borch et al. Tsygankov a a,b Maria Makarova Denis Chusov*a,c,d Reductive Amination Aldehydes and ketones can be converted into 1 o, 2 o and 3 o amines using reductive amination. Cool, dry location Biotage® MP-Cyanoborohydride is a macroporous polymer-supported cyanoborohydride,1 which is a solid-supported equivalent of tetraalkylammonium cyanoborohydride. STAB has been reported to undergo degradation when exposed to air, often requiring additional sub-stoichiometric reagent charges to drive reactions to completion. Reductive Amination of Proteins Several factors make reductive amination of sugars to proteins challenging. Reductive amination of AT- succinyl chitosan and lactose using sodium cyanoborohydride in a phosphate buffer (pH 6. Jan 29, 2015 · I am considering using sodium cyanoborohydride in a reductive N-alkylation of a polysaccharide, and want to know how to handle it safely and dispose of the nitrile byproduct. However, cyanide contamination resulting from the use of this reagent is of concern due to its Dec 19, 2020 · I am working on a reductive amination conjugation reaction between a tag I've synthesized and a glycan (I am using lactose to test out the protocol). Oct 1, 1979 · Citations (121) References (259) The reductive amination was performed following a protocol from Walton et al. Apr 22, 2020 · Hi, I'm interested to know if anyone has any experience with the reductive amination of MDP2P or P2P to its corresponding imine then amine using Sodium Cyanoborohydride. The first step is the nucleophiic addition of ammonia, a 1 o amine, or a 2 o amine to a carbonyl group to form an imine (Section 19-8). This reagent is known to be very effective for reductive amination and for the reduction of imines. Chem. The reductive amination Reductive Amination of MDP2P using Sodium Cyanoborohydride (NaBH3CN) by John Payne [ Back to the Chemistry Archive ] Sodium cyanoborohydride is most useful for the synthesis of MDMA and methamphetamine, less so for MDA. ACS Publications Apr 1, 1990 · An improved method for reductive alkylation of amines using titanium (IV) isopropoxide and sodium cyanoborohydride Reductive amination (Borch reaction) Reductive amination, sometimes called the Borch reaction, is the conversion of a carbonyl into an amine through an intermediate imine. It avoids the issue of repeated alkylations. The submitter has found that use of sodium borohydride instead of sodium cyanoborohydride in the present procedure results in the almost exclusive formation of cyclohexanol with less than 3% of basic material. A major reagent necessary for the completion of this reaction is a hydride source, commonly sodium cyanoborohydride (Na (CN)BH 3). Reductive amination, sometimes called the Borch reaction, is the conversion of a carbonyl into an amine through an intermediate imine. Aug 6, 2020 · One of the earliest examples of using organometallic catalysts for transfer hydrogenative reductive amination was reported by Ogo/Watanabe and co-workers in 2001, who used pentamethylcyclopentadienyl (Cp*) iridium catalysts and ammonium formate in water to convert aldehydes and ketones to 1° amines [19]. Role of Catalyst Home Reductive Amination Ex (NaCNBH3) Reductive Amination (NaCNBH 3) Examples: Example 1 To a solution of 10% AcOH in MeOH was added the SM (1 equiv) and dry acetone (5 equiv). 13 – 15 Such reagents, however, can Reductive Amination of MDP2P using Sodium Cyanoborohydride (NaBH3CN) by John Payne [ Back to the Chemistry Archive ] Sodium cyanoborohydride is most useful for the synthesis of MDMA and methamphetamine, less so for MDA. Afanasyev a Alexey A. Method one is carried out in methanol at a ph of >12 for 1hr, this resulted in a dark colouration Feb 19, 2025 · Sodium cyanoborohydride (CBH) is commonly used as a mild reducing agent in the reductive amination of aldehydes and free amines. The successful use of sodium cyanoborohydride is due to its stability in relatively strong acid solutions (~ pH 3), its solubility in hydroxylic solvents like methanol, and its different selectivities at different pH values. ) can be used as well. [3] The carbonyl is first treated with ammonia to promote imine formation by nucleophilic attack. Aldehydes and ketones can be converted into 1 o, 2 o and 3 o amines using reductive amination. This restricts the pool of amines to ammonia, primary, and secondary amines. [32], using sodium cyanoborohydride (NaBH 3 CN) as reducing agent. Feb 13, 2022 · 0 I'm planning to do a reductive amination reaction between methyl pyruvate and benzylamine using sodium triacetoxyborohydride, $\ce {NaBH (OAc)3}. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran and occasionally in acetonitrile. The carbonyl group is most commonly a ketone or an aldehyde. 363 mmol). $ Acetic acid is used as a catalyst for protonating the iminium ion intermediate. The bound cyanoborohydride can be utilized as a versatile reducing agent2,3 for the reductive amination of carbonyl compounds and reduction of imines. While it can be used for reductive amination, it requires careful addition or specific conditions to avoid reducing the starting carbonyls before imine formation and reduction can occur. Immobilization by reductive amination of amine-containing biological molecules onto aldehyde-containing solid supports is used to create matrices for affinity purification of antibodies and other molecules. Second, the equilibrium Dec 1, 2012 · The synthesis of secondary and tertiary amines by the reductive amination of aldehydes and ketones is usually and relatively fast and efficient. The utility of sodium cyanoborohydride as a reducing agent is greatly enhanced by its stability under acid conditions, and its The last step, the reduction of iminium ion, is what we also see in the reduction of nitriles with LiAlH 4. A simple and convenient procedure enables the reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids using sodium borohydride as reducing agent in 2,2,2- trifluoroethanol without use of a catalyst or any other additive. One common reducing agent for this purposes is sodium cyanoborohydride (NaBH 3 CN) which can selectively reduce imines in the presence of aldehydes. Patterns in Reductive Amination The main requirement for an amine to be used in reductive amination is the presence of a hydrogen on the nitrogen. Sodium cyanoborohydride is a similarly useful reagent. The process begins with the formation of an iminium cation through the reaction of a carbonyl with a primary amine in an acidic environment. Sodium cyanoborohydride (NaCNBH3) is not H2O sensitive and is typically used with MeOH as the solvent. This method is effective for a wide range of substrates, including aliphatic and aromatic aldehydes, and primary and secondary amines. Free cyanide species such as HCN and NaCN are known residual impurities in CBH that can contribute to the formation of undesired side products May 8, 2024 · Applications The applications of sodium cyanoborohydride are vast and varied. Hitchhiker’s guide to reductive amination A comparative study of various widely used methods of reductive amination Evgeniya Podyacheva a Oleg I. Org. At low pH (3-4), it effectively reduces aldehydes and ketones to the parent hydrocarbon. It is a chemical reaction that converts aldehyde and ketones into 1°, 2° and 3° amine. [4] . In this reaction a carbonyl group is converted to an amine via an imine intermediate, the formation of which is rate limiting. Tetrahedron Lett. Sodium cyanoborohydride (NaBH3CN) is a mild reducing agent that is commonly used in reductive aminations. 2K Views. Within the pharmaceutical industry, this reaction is employed in the bioconjugation of proteins and peptides. Instead of forming an imine, a reducing agent like sodium cyanoborohydride (NaBH 3 CN) is used to add hydrogen, resulting in a Looking at using sodium cyanoborohydride for a reductive amination but wondering what the safest way of quenching the reaction would be? I know… The document discusses the use of sodium triacetoxyborohydride as a reducing agent for the reductive amination of aldehydes and ketones. Jan 8, 2023 · The other reducing agent used most often for reductive amination is sodium cyanoborohydride (NaBH3CN). The reductive amination May 3, 2014 · The reductive amination using sodium cyanoborohydride (NaBH3CN) as the reducing agent is especially called the Borch reaction and has high generality. In the following example, the amine molecule has two R groups attached, therefore yielding a tertiary amine as the final product of reduction. Oct 21, 2019 · Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. Free Dec 2, 2009 · Reductive amination is a chemical reaction commonly employed by organic chemists in academics and the pharmaceutical industry. [3] Reductive amination, sometimes called the Borch reaction, is the conversion of a carbonyl into an amine through an intermediate imine. Sep 15, 2006 · Density Functional Theory Study on the Selective Reductive Amination of Aldehydes and Ketones over Their Reductions to Alcohols Using Sodium Triacetoxyborohydride. The Reductive Amination Explained: Reductive amination is a method that converts aldehydes and ketones into primary, secondary, and tertiary amines. 0) for 6 days was suitable for the preparation of lactosaminated M- succinyl chitosan (Fig. Jun 25, 1998 · r d amination (hydroamination) re ction. Jan 1, 1981 · The significance of these results relative to the mechanism of the reductive amination of carbonyl compounds with sodium cyanoborohydride and amine salts is discussed. The set of available complex borohydrides use inthis process isrestricted to This conclusion i confirmed bythe fact that dding several compounds such as sodium cyanoborohydride and phenylammonium borohydride solution (prepared prelimi-sodium or lithium triacetoxyborohydrides [1 -3]. Mechanism of Reductive Amination Aside from the reducing agents indicated in the given mechanism, other reducing agents could also be used. A variety of methods are available for the direct reductive amination of aldehydes and ketones using sodium borohydride and sodium cyanoborohydride [3], [4], [5], [6], [7]. All we need is to mix an amine with an aldehyde or ketone in the presence of sodium cyanoborohydride (NaBH 3 CN) at lower pH levels: Since the reaction rate for the reduction of iminium ions is much faster than for ketones or even aldehydes, the reductive amination can be carried out as a one-pot procedure by introducing the reducing agent into a mixture of the amine and carbonyl compound. Reductive amination is used for preparing amines from aldehydes and ketones. It is generally used for the reduction of imines. Total molecular weight of the conjugate is 689 The molecular formula for sodium cyanoborohydride, one of the most common reducing agents for reductive amination processes, is Sodium borohydride (NaBH4) is a more potent reducing agent and can readily reduce aldehydes and ketones. , 1971). Example procedures for reductive amination using sodium cyanoborohydride (NaCNBH3). This process typically yields a mixture of N-alkylated and N,N-dialkylated products due to the possibility of multiple condensation and reduction steps. Ti (iPrO)4 or ZnCl2] are sometimes added to improve yields for less reactive substrates. Feb 6, 2025 · Sodium cyanoborohydride (CBH) is commonly used as a mild reducing agent in the reductive amination of aldehydes and free amines. A detailed mechanism illustrating reductive amination using sodium cyanoborohydride (NaCNBH3). Recent studies show that at least a quarter of C–N bond-forming reactions in the This imine can then be reduced to an amine via a reducing agent, the most common one being sodium cyanoborohydride. We still start with a ketone or aldehyde and an amine, but our reducing agent is specifically sodium cyanoborohydride (NaBH 3 CN). It is a common method to make amines and is widely used in green chemistry since it can be done catalytically in one-pot under mild conditions. Jan 1, 1990 · Sodium triacetoxyborohydride is a reagent of choice in the reductive amination of aldehydes and saturated aliphatic ketones with primary and secondary amines. Oct 27, 2014 · Cyanoborohydride has a number of functions as a selective reducing agent, which are very much pH dependant: Reduction of aldehydes and ketones. This reduction is achieved by introducing a reducing agent, which donates a hydrogen atom to the imine and breaks the double bond, leading to the amine formation. Learn the nuances of reductive amination with NaBH3CN. 15,16 Some reported limitations are the requirement of a large excess of the amine,12 the sluggish reactions with aromatic ketones12 amines,17-20 and with weakly basic and A simple and convenient procedure allows the reductive amination of aldehydes and ketones using sodium borohydride as reducing agent and boric acid, p -toluenesulfonic acid monohydrate or benzoic acid as activator under solvent-free conditions. Sep 1, 2017 · This is called reductive amination and avoids the problem of multiple alkylations. In biochemistry, dehydrogenase enzymes Sep 5, 2023 · Reductive amination is the process of conversion of a carbonyl group to an amine through an imine ion intermediate. It also allows the reduction of α, β - unsaturated carbonyls to their corresponding unsaturated alcohols. The cyano group on this reagent plays a crucial role. [4] The carbonyl is first treated with ammonia to promote imine Sep 5, 2021 · Sodium triacetoxyborohydride (STAB) is a mild, selective, and frequently used reducing agent for reductive amination transformations. A regioselective reductive amination using sodium triacetoxyborohydride was employed in the construction of the pyrrolidine ring of (!)-communesin A: H3C CH3 O H3C N H3C O In a complex transformation, a tryptamine derivative and an enantioenriched dialdehyde were combined to give a cyclic bis-hemiaminal interemediate; electrophilic activation with trifluoroacetic anhydride initiated a Mannich Sodium cyanoborohydride is preferred as a reducing agent over sodium borohydride as the latter will also reduce the reactive aldehydes to hydroxyls at the same time as reducing the Schiff’s bases. 1 It is preferred to sodium cyanoborohydride (NaBH 3 CN) in many applications due to reduced toxicity of the side products formed, and better yields and reproducibility during synthesis. Feb 6, 2025 · ABSTRACT: Sodium cyanoborohydride (CBH) is commonly used as a mild reducing agent in the reductive amination of aldehydes and free amines. , 60 (15), 4928-9 (English) 1995: Reductive alkylation of dimethylamine using titanium (IV) isopropoxide and sodium borohydride: an efficient, safe, and convenient method for the May 14, 2001 · Sodium Cyanoborohydride -MDA reaction conditions , Hive Methods Discourse Dec 29, 2016 · TL;DR In this video, the reductive amination process of converting ketones or aldehydes into amines using sodium cyanoborohydride is explained, along with the mechanism and practice problems. Though examples of alternate conditions have been developed for large-scale reductive amination processes, STAB continues to be one of the most widely used reagents to perform reductive amination chemistry [2]. This reaction works on both aldehydes and ketones. Free cyanide species such as HCN and NaCN are known residual impurities in CBH that can contribute to the formation of undesired side products including Sodium triacetoxyborohydride (NaBH (OAc) 3) is particularly effective in reductive aminations due to its large scope, mildness, and selectivity. The carbonyl is first treated with ammonia to promote imine formation by nucleophilic attack. If desired, however, the double bond can be reduced to a more stable secondary amine bond using sodium cyanoborohydride (see section on reductive amination at the end of this page). One of its most prominent uses is in the reductive amination of aldehydes and ketones, a key method for the synthesis of amines from carbonyl compounds. The reaction was stirred at RT for 5 h. Reductive amination (also known as reductive alkylation) is a form of amination that converts a carbonyl group to an amine via an intermediate imine. Dec 2, 2009 · Reductive amination is a chemical reaction commonly employed by organic chemists in academics and the pharmaceutical industry. 12 mmol) and the aldehyde (31. After stirring 10 min, DCM was added to the reaction mixture. It is an excellent method to generate the imine of an amine with a suitable aldehyde or ketone, and then reduce the imine to an amine. , 35 (15), 2401-4 (English) 1994: Titanium (IV) isopropoxide and sodium borohydride: a reagent of choice for reductive amination J. . The control of the pH is important for effecting clean reductive amination. The most common reductants used for this application are sodium cyanoborohydride (NaBH 3 CN), 9 sodium triacetoxyborohydride (NaBH (OAc) 3), 10 organosilanes, 11, 12 and other similar reagents (Scheme 2). Reductive amination of aldehydes and ketones. These reactions occur <pH 7 because the iminium ions are the actual substrates. The solution was stirred at RT 1 h, after which time it was cooled to 0 C and treated with NaCNBH3 (1. The utility of sodium cyanoborohydride as a reducing agent is greatly enhanced by its stability under acid conditions, and its solubility in aprotic Sodium cyanoborohydride is a crucial reagent used in the reductive amination step of amino acid synthesis. Sodium cyanoborohydride meets these requirements and is by far the most common reducing reagent used for reductive amination of aldehydes to proteins. Microwave irradiation has been explored previously for significant improvements in reaction times of reductive amination using sodium borohydride and clay SiliaBond Cyanoborohydride (CBH) is the silica-bound equivalent of sodium cyanoborohydride. The reaction takes place in two parts. 3. Dec 29, 2016 · This organic chemistry video tutorial provides the mechanism of the reductive amination reaction of ketones and aldehydes. Sodium triacetoxyborohydride is a very mild reducing reagent that reduces iminium ions faster than it reduces aldehydes. The hydrazone bond is sufficiently stable for most protein-labeling applications. All the products are known and well Apr 9, 2014 · In summary, we have developed a mild, efficient and general reaction procedure for the direct reductive amination of bisulfite aldehyde adducts with amine hydrochlorides using sodium cyanoborohydride in methanol. Hydrazide reaction scheme for chemical conjugation to an aldehyde. Using a combination of literature online I have performed a few attempts with multiple results but never any desired product. The first step is the nucleophiic addition of the carbonyl group to form an imine. The Mar 5, 2025 · A regioselective reductive amination using sodium triacetoxyborohydride was employed in the construction of the pyrrolidine ring of (!)-communesin A: H3C CH3 O H3C N H3C O In a complex transformation, a tryptamine derivative and an enantioenriched dialdehyde were combined to give a cyclic bis-hemiaminal interemediate; electrophilic activation with trifluoroacetic anhydride initiated a Mannich Sodium triacetoxyborohydride is a general, mild, and selective reducing agent for the reductive amination of various aldehydes and ketones. Regular sodium borohydride would reduce the ketone immediately, preventing imine formation. Carbonyl compounds and primary amines undergo reductive amination first to produce imines, followed by secondary amines in the same reaction mixture, using selective reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride. Sodium cyanoborohydride (CBH) is commonly used as a mild reducing agent in the reductive amination of aldehydes and free amines. 5 equiv). However, Uncle Fester says that sodium cyanoborohydride gives him poor yields and he dismisses its usefulness. The Borch reductive amination technique stands out from conventional methods because it uses sodium cyanoborohydride (NaBH 3 CN) to effect selective reductions under mild acidic conditions. Acetic acid may be used as catalyst with ketone reactions. Commonly used reductant is sodium cyanoborohydride, NaBH 3 CN which has a similar reactivity with that of NaBH 4 but the former has a greater stability in acidic medium. The imine is then reduced to an amine by sodium cyanoborohydride. A reducing agent commonly used for this reaction is sodium cyanoborohydride (NaBH 3 CN). A major reagent necessary for the completion of this reaction is a hydride source, commonly sodium cyanoborohydride (Na (CN)BH3). Reductive amination is a key reaction involving the conversion of carbonyl compounds, such as aldehydes or ketones, into amines. STAB has a much-improved safety profile over similar selective reducing agents such as sodium cyanoborohydride. 18 mmol) in 1,4-Dioxane (3 mL) was stirred for 5 min then treated with NaBH (OAc)3 (77 mg, 0. A reducing agent commonly used for this reaction is sodium cyanoborohydride The overall reaction of carbonyl groups to primary amino groups using sodium cyanoborohydride is called reductive amination. The cyanoborohydride offers five times milder reduction compared to borohydride in the reductive amination process, reducing the Schiff’s bases, but not the aldehydes 2. Jun 13, 2005 · A simple and convenient procedure for reductive amination of aldehydes and ketones using sodium borohydride activated by boric acid, p -toluenesulfonic acid monohydrate or benzoic acid as reducing agent under solvent-free conditions is described. Sodium cyanoborohydride is a selective reducing agent used for a variety of chemical reductions, including aldehyde, ketones, oximes, enamines, reductive aminations of aldehydes and ketones, and reductive alkylations of amines and hydrazines. The presence of the electron-withdrawing cyano (CN) group makes it less reactive than sodium borohydride (NaBH4). Sodium cyanoborohydride is the most effective and commonly used reducing agent for reductive amination. This allows for a one-pot process for reductive animation. A regioselective reductive amination using sodium triacetoxyborohydride was employed in the construction of the pyrrolidine ring of (!)-communesin A: H3C CH3 O H3C N H3C O In a complex transformation, a tryptamine derivative and an enantioenriched dialdehyde were combined to give a cyclic bis-hemiaminal interemediate; electrophilic activation with trifluoroacetic anhydride initiated a Mannich Sep 25, 2025 · Description Sodium cyanoborohydride (NaBH3CN) is a selective reducing agent used for a variety of chemical reductions, including aldehyde, ketones, acetals, epoxides, oximes, enamines, reductive aminations of aldehydes and ketones, and reductive alkylations of amines and hydrazines. The traditional method of reductive amination involves the reaction of a carbonyl compound (aldehyde or ketone) with an amine in the presence of a reducing agent, such as sodium cyanoborohydride. The overall reaction of carbonyl groups to primary amino groups using sodium cyanoborohydride is called reductive amination. The hydride reagent is a derivative of sodium borohydride (NaBH 4), formed by replacing one H atom by CN. May 23, 2024 · Sodium cyanoborohydride is a selective reducing agent used for various chemical reductions, including aldehydes, ketones, oximes, enamines, reductive aminations of aldehydes and ketones, and reductive alkylations of amines and hydrazines. It discusses the use of reducing agents such as sodium cyanoborohydride Reductive Amination Aldehydes and ketones can be converted into 1 o, 2 o and 3 o amines using reductive amination. Lewis acids [ex. Jan 4, 2017 · An efficient one-pot procedure for the direct reductive amination of aldehyde and ketones was achieved in the presence of sodium borohydride by using B(OSO3H)3/SiO2(SBSA) as the reusable solid catalyst in acetonitrile and solvent-free conditions. The utility of sodium cyanoborohydride as a reducing agent is greatly enhanced by its stability under acid The reductive amination using sodium cyanoborohydride (NaBH3CN) as the reducing agent is especially called the Borch reaction and has high generality. syp2r e6luzz kej uk1q bhbn fqm wxxiqm6ng ylk drv9qt fmfc